Musculoskeletal regenerative engineering is an interdisciplinary research field and clinical approach focused on developing strategies to restore the structure and function of damaged or diseased musculoskeletal tissues. It integrates principles from engineering, biology, and materials science to employ cells, biomaterials, and signaling molecules for tissue repair, replacement, or regeneration.
Ontological type
Core Methods
Clinical Applications
Biomaterials and Scaffolds
Mechanobiology-Driven Strategies
2017 - 2018
Hierarchical Fabrication Techniques
2019 - 2020
Niche-Mimetic Biomaterials
2021 - 2021
Mechanobiology-Driven Strategies era
Ali Khademhosseini [1] is a prominent figure in musculoskeletal regenerative engineering during this era, with affiliations at the Harvard–MIT Division of Health Sciences and Technology [3] and Harvard University [4]. His key contributions include tendon tissue engineering using mechanical and biochemical stimulation to align stem cells on cell-laden hydrogel yarns, as described in Tendon Tissue Engineering: Effects of Mechanical and Biochemical Stimulation on Stem Cell Alignment on Cell-Laden Hydrogel Yarns [7], and enhanced skeletal muscle formation on microfluidic spun GelMA fibers with surface patterning and agrin treatment [8], advances that were essential for creating hierarchical, anisotropic scaffolds with multi-scale features. Wojciech Święszkowski [2] is a distinguished researcher affiliated with the University of Warsaw [5] and Warsaw University of Technology [6] during this era. In this period, his work on tendon tissue engineering co-authored Tendon Tissue Engineering: Effects of Mechanical and Biochemical Stimulation on Stem Cell Alignment on Cell-Laden Hydrogel Yarns [7], contributing to the development of hierarchical, anisotropic constructs crucial for load-bearing tendon and ligament engineering.